Lagging broken chromosomes rejoin daughter telophase nuclei by passing through channels in the newly-formed nuclear envelope to maintain euploidy. Image credit: Brandt WareckiA DNA thread (arrow) originating from telomeric regions connects sister chromatids segregating to opposing poles. Image Credit: Brandt WareckiU2OS cells expressing mNeonGreen-BAF and Halo-H2A (histone marker). Examples of DNA bridges in anaphase cells (top row) and telophase cells (bottom row). Image Credit: Alison MillsTimelapse in seconds of live Drosophila neuroblasts expressing GFP-BAF (nonspecifically labels DNA and the nuclear envelope). Top row is wild type and the bottom row is from a fly with a long third chromosome. The little arrows point to DNA threads. Image Credit: Alison MillsTime lapse of a devising U2OS cell expressing mNeonGreen-BAF and Halo-H2A (histone marker). Image Credit: Alison MillsThe Hail Mary of Mitosis: BubR1 coated DNA tethers throw a lifeline to acentric chromosome fragments. As a result, the acentrics are successfully incorporated into daughter nuclei during at the last moment in telophase.
